Tailor-made Catalysts for Asymmetric Hydrogenation of Ketones
نویسندگان
چکیده
منابع مشابه
Asymmetric Hydrogenation and Transfer Hydrogenation of Ketones
Optically active alcohols are important building blocks in the synthesis of fine chemicals, pharmaceuticals, agrochemicals, flavors and fragrances as well as functional materials (Arai & Ohkuma, 2011; Klingler, 2007). Furthermore, molecular hydrogen is without doubt the cleanest reducing agent, with complete atom efficiency. Therefore, the catalytic, asymmetric hydrogenation (AH) of prochiral k...
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Iridium complexes with chiral N,P ligands have established themselves as efficient catalysts for the asymmetric hydrogenation of olefins, with largely complementary scope to Rh and Ru diphosphane complexes. In contrast to Rh and Ru catalysts, they do not require a coordinating polar group next to the C=C bond. Initial experiments with cationic phosphanyloxazoline (phox) complexes ([Ir(1)(cod)]X...
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The acylation of alcohols catalyzed by N,N-dimethylamino pyridine (DMAP) is, despite its widespread use, sometimes confronted with substrate-specific problems: For example, target compounds with multiple hydroxy groups may show insufficient selectivity for one hydroxyl, and the resulting product mixtures are hardly separable. Here we describe a concept that aims at tailor-made catalysts for the...
متن کاملPhosphine-free chiral iridium catalysts for asymmetric catalytic hydrogenation of simple ketones
Novel pyridylalkylamine and aminopyridinato ligand stabilized iridium complexes with no P ligand are introduced. These complexes have been investigated as catalysts for asymmetric hydrogenation of simple ketones, resulting in an active catalyst for bulky alkyl aryl ketones that is a-methylpropiophenone. The ligands were synthesized from inexpensive starting materials and their modular design al...
متن کاملAn additional coordination group leads to extremely efficient chiral iridium catalysts for asymmetric hydrogenation of ketones.
The production of enantiopure chiral compounds is important for pharmaceutical and agrochemical industries because enantiomers can exhibit distinct biological activities. Therefore, processes that directly produce the desired enantiomer are desirable. First reported by Knowles, Horner et al. in 1968, catalytic asymmetric hydrogenation of unsaturated compounds such as olefins, ketones, and imine...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 2007
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.65.1070